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The simplified framework is expected to better focus peer reviewers on the key questions needed to assess the scientific and technical merit of proposed research projects: “Can and should the proposed research project be conducted?” To achieve this, the five current review criteria (defined as Significance, Innovation, Approach, Investigator, and Environment; derived from NIH peer review regulations ) are being reorganized into three broader factors to help reviewers focus on crucial questions that determine scientific merit. Reviewers will consider all three factors in determining the overall impact score, which reflects their overall assessment of the likely impact of the proposed research.

• Factor 1: Importance of the Research (Significance and Innovation), factor score 1-9
• Factor 2: Rigor and Feasibility (Approach), factor score 1-9,
• Factor 3: Expertise and Resources (Investigator and Environment), either rated as sufficient for the proposed research or not (in which case reviewers must provide an explanation)

A significant concern being addressed in the simplified framework is the potential for general scientific reputation to have an undue influence on application review. By changing the evaluation of Investigator and Environment to a binary decision of sufficient or not in the context of the proposed research, Factor 3 aims to help mitigate this potential biasing influence.

Another concern addressed in the new framework is the reliance on peer reviewers to assess policy compliance. Relying on peer reviewers for these tasks has the potential to distract them from their chief goal of assessing the scientific and technical merit of an application. To reduce reviewer burden, NIH staff will assume administrative responsibilities  related to the Additional Review Considerations of Applications from Foreign Organizations, Select Agents, and Resource Sharing Plans.

The underscored the need for resources and guidance for investigators, reviewers, and NIH staff. NIH therefore developed a new , which is now live and will serve as a central repository of information on this initiative. NIH is developing an integrated set of training events and resources to communicate the changes to applicants, reviewers, and NIH staff that will be rolled out over the next year. This support will begin with a webinar on November 3^rd, 2023 to provide the public with an overview of the new framework and what to expect over the upcoming year in preparation for implementation. You can learn more and .

NIH expects the simplified review framework to have minimal impact on how applications are written. The intent is simply to focus reviewers on the fundamental questions that we have always asked them to address in reviewing grant applications for their scientific and technical merit, while minimizing the impact of reputational bias. NIH will keep you updated through their , notices in the , and through the and blogs. NIH looks forward to working together with the community to continue to improve peer review.

Originally posted by NIH on October 19, 2023